In addition to the nuclear genome, the rapidly evolving noncoding region containing the D-loop in the D-loop in the mitochondrial genome is another DNA sequence that appears suitable for ascertaining genetic individuality. The maternal
inheritance
of
the mitochondrial DNA makes it possible to analyse nucleotide sequence of the mtDNA hypervariable region via polymerase chain reaction(PCR) whether individuals are maternally related, of not. However, no significant population data in Korean have
been
available to assess the potential of the mtDNA hypervariable region. By direct sequencing of each amplified DNA product, about 440 bp-long segment of the hypervariable control region I of mitochondrial DNA(mtDNA) from 100 Korean individuals have
been
studied. The data are analysed to get an information of genetic characteristics of the mtDNA hypervariable control region I in Korean Population.
Among these sequences 74 nucleotide sites are polymorphic, 69 nucleotides of which is substituted by transition(88.5%) and 9 nucleotides by transversion(11.5%). From one hundred Korean individuals 83 mtDNA lineage type are found ; 26 individuals
are
represented by nine different mtDNA types and the rest have each mtDNA type. Twenty-six individuals grouped by nine mtDNA types are confrmed to be the different one by the DNA typing of VNTR alleles of D1S80. In Korean population(n=100),
nucleotide
diversity of mtDNA hypervariable control region I is 0.95% on average, and gene diversity 0.982. The probability that two unrelated are genetically identical for this section of mtDNA is 0.018, resulting in 98.2% of power of discrimination(PD).
These
results suggest that more sequence analysis of the mtDNA hypervariable region containing control region II would be needed to distinguish one from others, who are not maternal relatives.
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